Do you have heard that diabetics medications can also lose weight ? Is it true ? Is it safe ? One of the medicines known to treat diabetes type 2 is metformin. Metformin is generic name of biguanide class medicine for diabetics. In fact, some people say the medicine didn’t do much, meanwhile others say it works for them, even for people who don’t have type 2 diabetes. Metformin stop the liver from making too much glucose, and also help glucose get into body’s cells. Weight loss happen because it decreases appetite in people who take metformin.
You have to discuss with your doctor the dose of metformin you take. If you have type 2 diabetes or prediabetes and are overweight, your doctor may prescribe metformin to lower your risk of diabetes, and to see if it can help you to lose weight. In fact, your doctor might prescribe metformin for weight loss even if you don’t have diabetes or prediabetes. This is called an off-label use, meaning that the FDA has not approved metformin as a weight-loss aid. As a result, there is less information about how effective it is for this purpose.
Metformin can upgrade insulin sensitivity, nevertheless of whether or not a person taking it has type 2 diabetes or insulin resistance. That rise of insulin sensitivity can retain glucose level, which prevents the hunger and appetence for carbohydrate that come with spikes and subsequent drops in blood sugar. With less appetence for carbohydrate it is easier to lose weight.
Metformin also decrease blood sugar level causes less likelihood that extra glucose will be stored as fat tissue in the body. And metformin also can improve sensitivity to leptin hormone that regulate energy balance by inhibiting hunger.
Although metformin is considered safe to consume it is also not recommended to drink alcohol on it. It also can negatively interact with certain medication such aspirin. People with kidney problems may have a rare side effect known as lactic acidosis (acid build up in the blood).
The most common side effects of consuming metformin are diarrhoea, headache, indigestion, gas, feeling weak, nausea and vomiting.
The drug itself is not a hasty remedy. The amount of weight lost also varies from person to person from four to seven pounds after two years. Using metformin without following other healthy habits may not make weight loss. People who follow a healthy diet and exercise while using metformin tend to lose most weight. It maybe because of metformin is thought to boost how many calories burned during exercise.
Other than biguanides class (metformin), there’s a class of type 2 diabetes drugs called glucagon-like peptide 1 (GLP-1) agonists that are taken by injection, but aren’t insulin. These drugs are similar to the natural intestinal hormone called incretin (mimic the effect of incretin). They increase β-cell growth and how much insulin your body uses. They decrease your appetite and how much glucagon your body uses. They also slow stomach emptying. These are all important actions for people with diabetes. These medications not only improve blood sugar control but may also lead to weight loss.
Drugs in the class include Dulaglutide (Trulicity) taken weekly, Exenatide (Byetta) taken twice daily, Exenatide extended release (Bydureon) taken weekly, Semaglutide (Ozempic) taken weekly, and Liraglutide (Victoza) taken daily.
Depending on the medication and the dose, weight loss may average about 3 – 5.5 pounds (1.5 kg – 2.5 kg) when using these medicines. If you’re actively trying to lose weight through lifestyle changes and the use of one of these medications, research has shown that the medicines may lead to around 6 – 9 pounds (2.8 kg – 4.2 kg) more weight loss.
The disadvantage to these medicines is that they have to be taken by injection, and they also have an adverse effect, some serious. Some of the more common side effects include nausea, diarrhea, and vomiting.
This class of antidiabetic drugs isn’t recommended if you have family history of medullary thyroid cancer or multiple endocrine neoplasia. Laboratory studies have linked these drugs with thyroid tumors in rats, but until more long-term studies are completed, the risk to humans isn’t known. This class of antidiabetic drugs also not recommended if you’ve had pancreatitis. Hypoglycemia are also a risk only if you’re taking another medication known to lower blood sugar.